Figure 1 shows the association of plasma markers of AD (Aβ42/Aβ40; pTau181), neurodegeneration (NfL), and neuroinflammation (GFAP) with measures of CP volume and microstructural integrity (as measured by T1 and T2), after adjusting for sex, age, hypertension status, and body mass index (BMI). The gene discussed is NEFL; the disease is Alzheimer disease.