TNF and Alzheimer disease: Age-related histone modifications have been also related to the onset and progression of several neurodegenerative disorders [131, 132]; in this regard, microglia histone H3 phospho (Ser10)-acetylation (Lys14) phosphorylation has been increasingly found in AD patients [133] and is associated with increased production of IL-1β, IL-6, and TNF-α [134], and NF-κB activity [135].