After poly(I:C) infection, there was a downregulation of Uchl1 expression, while the expression of Tlr3, Caspase3, Caspase12, NOD-like receptor thermal protein domain associated protein 3 (Nlrp3), Interleukin-1β (IL-1β), IL-6, and Tumor necrosis factor alpha (Tnfα) was significantly upregulated. The gene discussed is IL1B; the disease is infection.