However, in the subsequent subgroup analysis by histological type a significantly increased susceptibility to EAC-EGJ Siewert I/II cancer in the Greek population was uncovered in the homozygous TT models (OR: 4.177, P = 0.0382), suggesting that HOTAIR rs920778, C > T (T/C) polymorphism may pose a risk-factor in the aetiopathogenesis of the EAC in the West in a similar pattern as shown by previous studies for the ESCC carcinogenesis mechanism in the East [40, 41]. Here, HOTAIR is linked to esophageal squamous cell carcinoma.