CCNB2 was significantly correlated with important TILs in ccRCC, including activated CD4 T cells (Act CD4 cells; ρ = 0.667, p < 0.001), activated CD8 T cells (Act CD8 cells; ρ = 0.416, p < 0.001), gamma delta T cells (Tgd cells; ρ = 0.384, p < 0.001), type 2T helper cells (Th2 cells; ρ = 0.377, p < 0.001), T follicular helper cells (Tfh cells; ρ = 0.349, p < 0.001), and myeloid-derived suppressor cells (MDSC; ρ = 0.348, p < 0.001) (Fig. 5E–J). This evidence concerns the gene CD4 and nonpapillary renal cell carcinoma.