Multiple members of the POZ/BTB family are also associated with monogenic NDD, e.g., ZBTB7A (OMIM 619769) (Ohishi et al. 2020), ZBTB11 (OMIM 618383) (Fattahi et al. 2018), ZBTB18 (OMIM 612337) (de Munnik et al. 2014), and ZBTB20 (OMIM 259050) (Cordeddu et al. 2014). The gene discussed is ZBTB20; the disease is Neurodevelopmental delay.