For example, homozygous mutations in NIN and KIF2A, encoding two components of the subdistal centriolar appendage, are linked to Sickler syndrome type 7 (OMIM 614851) and a syndrome of complex brain malformations (OMIM 615411), respectively (Dauber et al. 2012; Poirier et al. 2013). This evidence concerns the gene NIN and cerebral malformation.