The insulin-based measures of IR included the homeostatic model assessment for insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index,22 while the non-insulin-based measures included the triglycerides and glucose index (TyG index), the combination index of triglycerides, glucose and BMI (TyG–BMI index), the ratio of triglycerides and HDL-c (TG/HDL-c ratio) and the METS-IR.23–25. This evidence concerns the gene INS and Insulin resistance.