RAB3D and cancer: The rab3d and adgre5 homologs have been associated with the malignant phenotype of several human cancers (Mehner et al., 2014; Safaee et al., 2013; Ward et al., 2018), reflecting that Xiphophorus tumors recapitulate pathways that are relevant to malignant progression in human cancer and thus have high construct validity for modeling human cancer.