The rab3d and adgre5 homologs have been associated with the malignant phenotype of several human cancers (Mehner et al., 2014; Safaee et al., 2013; Ward et al., 2018), reflecting that Xiphophorus tumors recapitulate pathways that are relevant to malignant progression in human cancer and thus have high construct validity for modeling human cancer. This evidence concerns the gene ADGRE5 and cancer.