MITF and neoplasm: Coexpression of Xiphophorus cdkn2ab in medaka transgenic for the mitfa:xmrk melanoma-inducing gene resulted in full suppression of melanoma development, whereas CRISPR/Cas9-mediated knockout of the endogenous cdkn2ab in the mitfa:xmrk transgenic medaka strongly enhanced tumor growth (Regneri et al., 2019).