In the same preprint, embryos from the mitf:xmrk transgenic melanoma medaka line that were injected at the one-cell stage with the X. birchmanni adgre5 transgene driven by a pigment cell-specific promoter displayed only a few transformed pigment cells, whereas those expressing the X. malinche adgre5 did not show this reduced transformation effect (Garcia-Olazabal et al., 2023 preprint). This evidence concerns the gene MITF and melanoma.