TM6SF2 and Cirrhosis: As lipid turnover–related genes, PNPLA3 rs738409 variant and TM6SF2 rs58542926 variant are involved in abnormal hydrolysis of triglycerides and very-low-density lipoprotein secretion (162), which are significantly associated with a higher risk for alcohol-associated cirrhosis and may predispose patients with cirrhosis to A-HCC (93, 163).