Since hypoxia and starvation activate HIF1A signaling leading to the maturation of AEP, the binding of DDX3X to AEP resulted in a cleavage event at its Asn124 site and generated two truncated proteins, referred to as tDDX3X-N (amino acid 1-124) and the carboxyl-terminal DDX3X (tDDX3X-C) (amino acid 125-662) in tumor cells. This evidence concerns the gene HIF1A and neoplasm.