To examine the relationship between KIBRA and pathogenic tau in different tauopathies, we performed immunoblot analyses on human brain homogenates from the middle temporal gyrus of control, AD, and Pick’s disease cases characterized by neuropathology (Figure 1A and Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/JCI169064DS1). This evidence concerns the gene MAPT and frontotemporal dementia.