To test the impact of CT-KIBRA treatment after the onset of memory impairment in aged tauKQhigh mice, injections of lenti-CT-KIBRA or lenti-control into bilateral hippocampi were performed on tauKQhigh mice and ntg littermates at 10–12 months old and behavior tests were performed 4–6 weeks later. The gene discussed is WWC1; the disease is memory impairment.