Lipids, however, have also been implicated in AD and morespecifically in Aβ plaque formation.3 This is largely motivated by that the ε4 allele of the apolipoproteinE encoding gene (APOE), a lipid transporter, is the most prominentgenetic risk factor for developing sporadic AD.4 Additionally, recent genome-wide association studies (GWAS)have identified multiple lipid-sensing or lipid transporter proteinsassociated genes as AD risk factors (e.g., TREM2, CLU, ABCA7).5 The gene discussed is CLU; the disease is Alzheimer disease.