LILRB2 and Alzheimer disease: In addition to aging and AD leading to increase in protein levels of both LILRB2 receptor [97] and its ligands [97,103], many pathological conditions further exacerbate this process, raising the probability of excessive excitatory synaptic weakening and removal via LILRB2 [1,3,80,91,95,96,111,115–118] (Figure 1).