NR1H4 and fatty liver disease: As previously reported, BAs are regulated by farnesoid X receptor (FXR), of which 95% are actively reabsorbed in the terminal ileum and recycled in the liver, and FXR plays an important role in regulating lipid metabolism and suppressing inflammation in the liver.50 As a result, the underlying cause of the increased bile acids in the feces of patients with hepatic steatosis suggests an impairment of FXR function.