Engagement of CD160 on NK cells induces potent effector functions, even in the context of HIV infection,40, 41, 42, 43 while there are contradictory reports of the inhibitory or activating nature of signalling through Tim‐3 and TIGIT.44, 45, 46, 47, 48, 49, 50, 51, 52, 53. This evidence concerns the gene HAVCR2 and HIV infectious disease.