Engagement of CD160 on NK cells induces potent effector functions, even in the context of HIV infection,40, 41, 42, 43 while there are contradictory reports of the inhibitory or activating nature of signalling through Tim‐3 and TIGIT.44, 45, 46, 47, 48, 49, 50, 51, 52, 53. Here, CD160 is linked to HIV infectious disease.