Finally, utilizing single-cell RNA sequencing and cellular indexing of transcriptomes and epitopes (CITE) to analyze BCP-ALL patient samples revealed an augmentation of a non-classical monocyte subpopulation within the myeloid population compartment of leukemic BM at diagnosis and relapse, with inferior relapse free and OS (16, 17) Thus, non-classical monocytes may be generated in response to leukemia-induced tissue inflammation to restore damaged endothelium in a BM infiltrated by LCs. Here, OPN1SW is linked to acute lymphoblastic leukemia.