MICA and acute lymphoblastic leukemia: It was observed that MICA/B was not expressed at detectable levels in NK-resistant LC, suggesting that the common resistance of BCP-ALL blasts to NK cell cytotoxicity may not be caused by inhibitory pathways commonly relevant in tumors, including HLA-G expression, lack of CAMs, or perforin resistance, but rather by the lack of NK cell activation by MICA/B (128).