Examination of CXCL16-positive myeloid cells revealed enrichment of well-known immunosuppressive markers/phenotypes (C5Ar1 and CXCR4) (28–31) as well as inflammatory myeloid cells (CD93 and HLA-DPB1) (32–35), suggesting increased pleiotropic RNA expression in these subsets of GBM cells (Figure 1B, right panel). Here, CXCR4 is linked to glioblastoma.