The study revealed that CXCR6 expression is associated with activated and exhausted T cells, especially CD8+ T cells, while CXCL16 expression in myeloid cells is correlated with immunosuppressive phenotypes in both mouse and human GBM datasets, indicating a potential role for CXCR6 in modulating T-cell infiltration and function in GBM. Here, CXCR6 is linked to glioblastoma.