CD8A and neoplasm: The first observation was that there was an increased T cell: myeloid cell ratio in the CXCR6 knockout tumor microenvironment, which is suggestive of a more inflammatory tumor (1.8 ± 0.2 vs. 4.6 ± 1.1 T-cell/TAMC ratio, 2.6 ± 0.5 vs. 5.0 ± 1.2 CD8/TAMC ratio, and 0.5 ± 0.2 vs. 1.9 ± 0.5 CD4/TAMC ratio in the control versus CXCR6 KO, respectively) (Figure 3C).