As our previous data clearly indicated that immunosuppressive myeloid cells express surface-bound CXCL16, we reasoned that even though CXCR6 is needed for T cells to infiltrate GBM tissue, once in the tissue, the CXCR6/CXCL16 interaction may foster immunosuppression in T cells by fostering interactions between T cells and immunosuppressive TAMCs. This evidence concerns the gene CXCR6 and glioblastoma.