Recent investigations have illuminated the central role of regulatory T cells (Tregs) in orchestrating immune modulation and tissue restoration, infiltrating the aftermath of stroke and rousing microglia via osteopontin (OPN) secretion, thereby igniting the generation of oligodendrocyte progenitor cells (OPCs) and the rejuvenation of myelin sheaths (25). The gene discussed is SPP1; the disease is stroke disorder.