GRIA2 and Alzheimer disease: Several studies have found significant decreases in the efficiency of GluA2 Q/R site editing in human AD brains (Akbarian et al., 1995; Gaisler-Salomon et al., 2014; Khermesh et al., 2016; Annese et al., 2018) which may cause a pathological change in the function of AMPARs via excitotoxicity (Van Damme et al., 2002; Vieira et al., 2010; Sebe et al., 2017).