WWP2 and Alzheimer disease: We found that the J20 mice model of AD, at a time-point exhibiting spatial memory deficits, exhibits an upregulation of the AMPAR subunit GluA3 and RNA editing enzyme ADAR1 p110 as well as a downregulation of the RNA editing enzyme ADAR2, but no change in GluA1, GluA2, GluA4, ADAR1 p150, ADAR3, PIN1, WWP2, FXR1P, or CREB1, when compared to WT mice.