We found that the J20 mice model of AD, at a time-point exhibiting spatial memory deficits, exhibits an upregulation of the AMPAR subunit GluA3 and RNA editing enzyme ADAR1 p110 as well as a downregulation of the RNA editing enzyme ADAR2, but no change in GluA1, GluA2, GluA4, ADAR1 p150, ADAR3, PIN1, WWP2, FXR1P, or CREB1, when compared to WT mice. This evidence concerns the gene CREB1 and Alzheimer disease.