GRIA3 and amyotrophic lateral sclerosis: An increase in GluA3 has also been observed in ALS, where it appears that the co-occurrence of ADAR2 downregulation and upregulation of GluA3-containing AMPARs in motor neurons is associated with excitotoxicity and neuronal death (Rembach et al., 2004; Kwak et al., 2010; Gregory et al., 2020).