Moreover, it has been hypothesised that CREB1 may act to induce GluA2 expression through the well-established FosB pathway, which has been strongly implicated in AD pathology in both mice and humans (Carlezon et al., 1998; Kelz et al., 1999; McClung and Nestler, 2003). This evidence concerns the gene GRIA2 and Alzheimer disease.