SARS-CoV-2 has tropism for the choroid plexus epithelium, meninges, and brain vasculature as the SARS-CoV-2 entry proteins ACE2 and TMPRSS2 are both expressed at these sites, which has been suggested as the underlying mechanism of dysregulated CSF hydrodynamics seen in COVID-19 (Yang et al., 2021). Here, TMPRSS2 is linked to COVID-19.