Five of the 5,810 targets found to be most relevant with AD include; sortilin-related receptor 1 (SORL1), amyloid precursor protein (APP), phosphatidylinositol binding clathrin assembly protein (PICALM), upstream stimulatory factor 1 (USF1) and presenilin-1 (PSEN1). Here, PSEN1 is linked to Alzheimer disease.