Interestingly, opposite to the down-regulated expression of VentX in TAMs and its implications in the immunopathogenesis and treatment of cancer, elevated VentX expression in mononuclear phagocytes has been implicated in pathogenesis and treatment of autoimmune inflammatory disorders, such as RA/SLE and IBD.20 The gene discussed is VENTX; the disease is systemic lupus erythematosus.