Normothermia TTM upregulated 13 genes associated with hearing loss, including Loxhd1, Tecta, Zmiz1, Espn, Gjb2, Sesn3, Bdp1, Hg, Pax3, Rnls, Syne4, P2rx2, and Pou3f4. The gene discussed is ESPN; the disease is hearing loss disorder.