Normothermia TTM upregulated 13 genes associated with hearing loss, including Loxhd1, Tecta, Zmiz1, Espn, Gjb2, Sesn3, Bdp1, Hg, Pax3, Rnls, Syne4, P2rx2, and Pou3f4. Here, POU3F4 is linked to hearing loss disorder.