Normothermia TTM upregulated 13 genes associated with hearing loss, including Loxhd1, Tecta, Zmiz1, Espn, Gjb2, Sesn3, Bdp1, Hg, Pax3, Rnls, Syne4, P2rx2, and Pou3f4. This evidence concerns the gene SESN3 and hearing loss disorder.