The prevalence of H. pylori infection was significantly greater in patients with scrub typhus than in the healthy population, and the type I H. pylori strain was an independent risk factor for scrub typhus, Moreover, individuals infected with type I H. pylori are more susceptible to experiencing multiple organ damage associated with scrub typhus, suggesting that H. pylori carrying the CagA gene may promote and exacerbate scrub typhus. The gene discussed is S100A8; the disease is scrub typhus.