IL27 and Alzheimer disease: Analyzing independent gene expression data, we found that the hub genes enriched in type 1 IFN signaling were not only differentially expressed between healthy and AD lesional skin, but also between non-lesional and lesional AD skin (GSE5667, GSE32924).31, 32, 33, 34 This suggests the involvement of IL-27 and type 1 IFN signaling in AD.