IFI44L and Alzheimer disease: Four expression datasets (GSE5667, GSE32924, GSE27887, GSE32473) were downloaded from the GEO database to study the association of hub genes to AD phenotypes and treatment regimens.31, 32, 33, 34, 35, 36 In GSE5667, we observed that all hub genes, except for IFI44L, were upregulated in skin biopsies of lesional AD skin compared to in normal skin (Fig. 6).