T cell survival and the activity of cytotoxic lymphocytes are also enhanced due to type 1 IFN signaling, and a study found that autoreactive cytotoxic CD8 T cell numbers were elevated in AD patients upon induction by the autoallergen hom s 2.68, 69, 70, 71 Together, the autoallergens released during tissue damage due to excessive cytotoxic T cell activities and enhanced antigen presentation can elicit the autoallergy observed in AD.72, 73, 74, 75, 76 From our own serum data, the presence of autoallergy following upregulation of LOC100294145 was also suggested. Here, CD8A is linked to Alzheimer disease.