Ghasemi et al. showed that the 12-month treatment with 500 mg saffron tablets three times a day led to the regulation of T cells movement to CNS by reducing the serum levels of matrix metalloproteinases 9 (MMP-9) and increasing the serum levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) in MS patients [98]. Here, TIMP1 is linked to myeloid sarcoma.