In several cases, analysis of a pre-defined set of 19 known candidates implicated in language related syndromes, could identify probable pathogenic gene variants in the genes ERC1, GRIN2A and SRPX2. Potential pathogenic variants, identified in the genes SEMA6D, AUT2 and ROBO1, co-segregated with the language disorder in affected relatives of the respective probands. The gene discussed is SEMA6D; the disease is language disorder.