Progress in molecular targeted drugs has prolonged survival (Li et al., 2023), particularly in patients with lung cancer harboring epidermal growth factor receptor (EGFR) mutations (i.e., erlotinib, gefitinib, afatinib, dacomitinib, and osimertinib) or anaplastic lymphoma kinase (ALK) rearrangement (i.e., ceritinib, alectinib, brigatinib, ensartinib, lorlatinib), and in patients with breast cancer harboring human epidermal growth factor receptor 2 (HER2) amplification (i.e., trastuzumab). This evidence concerns the gene ERBB2 and breast carcinoma.