VEGFA and colonic neoplasm: Moreover, it has been proved that lactoferrin could reduce the growth of blood vessels in colon cancer cells and the mechanism was validated to be associated with the inhibition of angiogenesis related pathways, including VEGFR2, vascular endothelial growth factor A (VEGFA), PI3K, Akt, and Erk1/2 (Li et al., 2017).