CA2 and temporal lobe epilepsy: Interestingly, altered CA2 neuronal activity was found in animal models of neurodevelopmental disorders like ASDs and schizophrenia (Piskorowski et al., 2016; Modi et al., 2019; Donegan et al., 2020) or in sclerotic hippocampal tissue surgically excised from patients affected by temporal lobe epilepsy (Wittner et al., 2009).