Recent studies have highlighted the beneficial effects of IGF-2 in ameliorating cognitive deficits in aged-rats, in the BTBR mouse model of ASDs and in the Ube3A maternal-deficient (m-/p +) mouse model of Angelman syndrome (Steinmetz et al., 2016, 2018; Cruz et al., 2021). The gene discussed is IGF2; the disease is Angelman syndrome.