IGF2 and neurodevelopmental disorder: As previous studies provide evidence that IGF-2 is effective in rescuing social deficits occurring in mice models of neurodevelopmental disorders (Steinmetz et al., 2018; Cruz et al., 2021), we sought to test the effectiveness of IGF-2 in treating social deficits of the NLG3–/y mice, a monogenic model of ASDs (Baudouin et al., 2012).