GCG and diabetes mellitus: That said, increased islet content (ex vivo) (Orci et al., 1976; Baetens et al., 1978; Abdel-Halim et al., 1993) and secretion (in situ and in vitro) (Hermansen et al., 1979; Weir et al., 1981; Abdel-Halim et al., 1993) of SST under low glucose conditions have long implicated SST in the pathogenesis of defective glucagon counterregulation in animal models of diabetes.