More recently, Vergari et al. measured glucose-dependent SST secretion in the islets of hyperglycemic mice lacking the Krebs cycle enzyme fumarate hydratase in pancreatic β cells (Fh1βKO), a model of progressive insulin deficiency reminiscent of T2D (Adam et al., 2017; Vergari et al., 2020). This evidence concerns the gene SST and type 2 diabetes mellitus.