In intact isolated islets from humans with T2D, glucagon secretion at 1 mmol/L glucose was lower (65% on average) than in non-diabetic human islets, though, a reciprocal trend towards elevated SST secretion failed to reach statistical significance as it did in Fh1βKO mouse islets (Vergari et al., 2020). The gene discussed is SST; the disease is type 2 diabetes mellitus.