INS and early-onset autosomal dominant Alzheimer disease: GLUT4 has also been linked to Alzheimer’s disease, with several lines of research converging to suggest that the insulin-responsive glucose transporter GluT4 plays a key role in hippocampal memory processes, and that decreased activation of this transporter may underpin the cognitive impairment seen as a consequence of insulin resistance (McNay and Pearson-Leary, 2020).