Previous evidence has indicated the important role of HDAC6 in tau-mediated neurodegeneration, and HDAC6 may be involved in various neurodegenerative diseases such as AD, Parkinson disease, amyotrophic lateral sclerosis, and Huntington disease (Zhang et al., 2013; Trzeciakiewicz et al., 2020; Li et al., 2022). Here, MAPT is linked to amyotrophic lateral sclerosis.