SNED1 and Alzheimer disease: SNED1-associated DMPs cg15361291 [OR = 0.48, 95% CI (0.36–0.65), p = 2.49E-06] and cg21239079 [OR = 0.55, 95% CI (0.43–0.71), p = 5.53E-06] and ZNF727-associated DMP cg13947469 [OR = 0.74, 95% CI (0.58–0.94), p = 1.33E-02] showed protective associations with the risk of progression to AD from LMCI (Figures 6C, D; Supplementary Table S12).