HOXC5- and HOXC6-associated DMP cg08254359 was significantly correlated with the cognitive decline speed (Figure 8; Supplementary Table S14), namely, mPACCdigit_speed (r = −0.12, p = 2.76E-02) and mPACCtrailsB_speed (r = −0.12, p = 2.92E-02). The gene discussed is HOXC5; the disease is Mental deterioration.