The OR values from the logistic regression model indicated that HDAC6-associated DMP cg24616736 [OR = 1.67, 95% CI (1.08–2.62), p = 2.33E-02], ZNF502-associated DMP cg14768256 [OR = 1.53, 95% CI (1.16–2.02), p = 2.57E-03], HOXC5- and HOXC6-associated DMP cg08254359 [OR = 1.41, 95% CI (1.01–1.97), p = 4.30E-02], and HOXD8-associated DMP cg07783843 [OR = 1.75, 95% CI (1.15–2.71), p = 1.04E-02] were associated with increased susceptibility to AD in LMCI subjects (Figures 6C, D; Supplementary Table S12). Here, HOXC6 is linked to Alzheimer disease.