Most of them, including ZNF502, ZNF727, ZNF415, ZNF385B, ZNF232, ZNF200, and ZC3H14, have been validated as critical genes implicated in the pathogenesis of AD (Cassandri et al., 2017; Roubroeks et al., 2020; Vasanthakumar et al., 2020; Bu et al., 2021; Li et al., 2021). Here, ZNF727 is linked to Alzheimer disease.