For example, SNED1, which is associated with the top hit DMPs, has been demonstrated to function as a promoter of breast cancer metastasis and amyotrophic lateral sclerosis, and its abnormal expression significantly affects the survival outcome of these patients (Naba et al., 2014; Tarr et al., 2019; Krushkal et al., 2020; Barqué et al., 2021; Vallet et al., 2021). This evidence concerns the gene SNED1 and breast cancer.