In colorectal cancer cells (CRCs) and hepatocellular carcinoma cells, sphingomyelin phosphodiesterase 3 (SMPD3) is also involved in miRNA encapsulation, and SMPD3 inhibition decreases exomiR levels in CRC cells while increasing intracellular miRNA levels [71]. This evidence concerns the gene SMPD3 and colorectal cancer.