Among them, the variant (rs738409 c.444 C>G, p.I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3), which influences the activity of the PNPLA3 enzyme resulting in increased accumulation of fat in the liver, has been associated with predisposition to fatty liver disease and HCC (20, 21). The gene discussed is PNPLA3; the disease is hepatocellular carcinoma.