They encapsulated Hiltonol (toll-like receptor 3 agonist as a typical immune adjuvant) and human neutrophil elastase (ELANE, an immunogenic cell death inducer) inside the Tex, named Hiltonol-ELANE-α-LA-engineered exosomes (HELA-Exos), as an in-situ DC vaccine for the treatment of breast cancer (68). This evidence concerns the gene ELANE and breast carcinoma.