Our results indicated that ADRB1 (1165G > C) was not associated with stroke occurrence in hypertensive patients without diuretics, and ADRB1 (1165G > C) was associated with stroke risk in hypertensive patients with diuretics, possibly because the patients without diuretics were those with a shorter course of the disease and a lower BP level. This evidence concerns the gene ADRB1 and Stroke.