BRCA1 and cancer: Less prevalent genes of potential therapeutic relevance were also differentially mutated between race, including a decreased frequency of mutations in DNA repair pathway genes (ATM, BRCA2, and BRCA1) and subunits of the SWItch/sucrose non-fermentable (SWI/SNF) chromatin complex (SMARCA4 and ARID1A) in both Asian and Black patients across multiple cancer types (Fig. 1).