ITGAM and acute kidney injury: Recently, new studies have shed light on the behavior of KRM and IM subsets during AKI.76,120, –122 To understand how macrophages of each origin respond to AKI, Yao and colleagues performed scRNAseq on CD11b and F4/80 positive cells isolated from the kidneys of mice 1 or 3 days post 45 minutes of unilateral IRI.121 Analysis of combined scRNAseq at all time points revealed four clusters of KRM, including MHC2hi, Ccl4hi, Mrc1hi, and Slc40a1hi subsets.