CCR2 and acute kidney injury: For example, loss of IM (via Ccr2 knockout) did not affect cisplatin-induced AKI, whereas LC treatment to deplete KRM improved phenotypic outcome.137 However, it should be noted that these studies used a repeated low-dose cisplatin injection to induce AKI, which may alter macrophage response and involvement when compared with mice receiving a single injury event to induce AKI.