GRN and frontotemporal dementia: Alignment was also seen in patients with frontotemporal dementia that harbored a mutation in the grn gene, but not in patients with sporadic disease [68] In patients with Huntington’s disease, alignment was observed to transcriptomes from caudate nucleus but not Brodmann’s area 9, indicating specificity to processes related to protein aggregation and active neurodegeneration [69, 70].