The genes targeted by the miRNA significantly increased in female AD patients (hsa-miR-105-3p) included CBLN2, GOLIM4, and UHMK1 and the two miRNAs significantly decreased (hsa-miR-431-3p and hsa-miR-767-5p) included MDM2, MTCH2, and MTRNR2L1. The genes targeted by the two miRNAs significantly increased in male AD patients (hsa-miR-491-3p and hsa-miR-3149) included NOM1 and ZNF226, while the genes targeted by the two miRNAs significantly decreased represented a list of 71 genes. The gene discussed is ZNF226; the disease is Alzheimer disease.