The top genes targeted by miRNAs significantly altered in male AD patients included LARP1, FUS, BAZ2A, KMT2D, and DICER1; the three miRNAs underexpressed in male AD patients targeted BTBD3, NDN, NUP43, PIK3C2B, RAC1, RASA1, RCAN2, RNF38, and RPRM. The gene discussed is NDN; the disease is Alzheimer disease.