Similarly, gene expression profiling analysis of various prostate cancer cell lines from the CCLE database demonstrated that, compared with that in the benign prostatic hyperplasia cell line BPH-1, CEL gene expression was decreased in most prostate cancer cells, while PDE6G and CYP3A4 gene expression was increased (Fig. 12B). The gene discussed is CYP3A4; the disease is prostate carcinoma.