By integrating genomics, transcriptomics, and proteomics data retrieved from several public datasets, genome-wide metabolic models (GEMs) stratified HCC patients into three prognostic subgroups with significant differences in dysregulated kynurenine metabolism (iHCC1), WNT/β-catenin-related lipid metabolism (iHCC2), and PI3K/AKT/mTOR signaling (iHCC3) [24]. The gene discussed is MTOR; the disease is hepatocellular carcinoma.