RUNX2 and pachyonychia congenita: The JASPAR database (http://jaspar.genereg.net/) revealed potential RUNX2-binding sites on the GAMT promoter, and the top three motifs are shown in Fig. 7C. The GEPIA database was used to analyze GAMT expression in 179 PC tissues and 171 normal tissues; GAMT was significantly downregulated in PC tissues (Fig. 7D).