Torii et al. showed that UVA light (360–400 nm), absent in commonly used indoor lights (Fig. 2E), could suppress myopia progression and reduce axial elongation in humans through the upregulation of the transcription factor early growth response factor-1 (EGR-1), encoded by the EGR1 gene [103], and via neuropsin (OPN5) stimulation in mice [104]. Here, OPN5 is linked to myopia.