Lastly, inference of immune repertoire from RNA-seq data using TRUST4 algorithm [26] again showed heterogenous TCR and BCR clonotype abundance changes, whereas the evaluation of the tumor samples from a patient who achieved pCR harbored the highest number of TCR and BCR clonotypes at pre-run-in and maintained this after treatment (Fig. 4J). The gene discussed is BCR; the disease is neoplasm.