Subsequently, we conducted stratified analysis stratified by age (< 60, ≥ 60), sex, obesity, MetS, and hs-CRP category (< 2.5, ≥ 2.5), and the results of subgroup analysis of NAFLD and OA were presented in Fig. 2. This evidence concerns the gene MAP3K14 and obesity due to melanocortin 4 receptor deficiency.