Compared with normal tissues, BAG3 was downregulated in kidney renal cell carcinoma, kidney renal papillary cell carcinoma, kidney chromophobe, bladder urothelial carcinoma, prostate adenocarcinoma, stomach adenocarcinoma, and uterine corpus endometrial carcinoma while BAG3 was upregulated in cholangiocarcinoma, liver hepatocellular carcinoma, lung adenocarcinoma, lung squamous cell carcinoma and thyroid carcinoma (Fig. 1A). This evidence concerns the gene BAG3 and chromophobe renal cell carcinoma.