Compared with normal tissues, BAG3 was downregulated in kidney renal cell carcinoma, kidney renal papillary cell carcinoma, kidney chromophobe, bladder urothelial carcinoma, prostate adenocarcinoma, stomach adenocarcinoma, and uterine corpus endometrial carcinoma while BAG3 was upregulated in cholangiocarcinoma, liver hepatocellular carcinoma, lung adenocarcinoma, lung squamous cell carcinoma and thyroid carcinoma (Fig. 1A). The gene discussed is BAG3; the disease is prostate adenocarcinoma.