To investigate the binding abilities of the active components in TGT with osteosarcoma targets, we performed molecular docking using the top ten target genes based on their degree values (EGFR, VEGFA, JUN, STAT3, HSP90AA1, ESR1, PTGS2, AR, HDAC1, and CDK1) as protein receptors, and the active components (Dihydroconduritol, D-oleandrose, Marsdekoiside, Tenacigenin B, Tenacissoside G, D-glucose, Saccharose, Taraxasterol, Tenacissoside J, and Tenacissoside L) as ligands. Here, HDAC1 is linked to osteosarcoma.