As we identified Ep_FXYD2 as a premalignant ductal-like population, we annotated a group of TFs corresponding to Ep_FXYD2 as “Ductal-associated.” As expected, NR5A2, an essential element for constraining pancreatic cancer initiation [41], was included in the “Ductal-associated” TF cluster. Here, NR5A2 is linked to familial pancreatic carcinoma.