In addition, GSEA using WikiPathways (https://www.wikipathways.org/) gene sets showed enrichment of inflammation-related gene sets, such as ‘immune infiltration in pancreatic cancer’, ‘CCL18 signaling pathway’, and ‘overview of proinflammatory and profibrotic mediators’, in the control cells compared to the METTL3 knockdown cells (P < 0.05; Fig. 3d). This evidence concerns the gene CCL18 and familial pancreatic carcinoma.